Evidence has been shown that the high dose of immunosuppressive therapy followed by a stem cell transplant can influence remission of the relapsing-remitting multiple sclerosis. Multiple sclerosis is an autoimmune disease where the immune system attacks and invades the central nervous system.
Clinical trials over the course of 5 years give great hope that this type of treatment will result in the remission of relapsing-remitting multiple sclerosis. Of the 69 percent that participated in the trial, progression of the relapsing-remitting multiple sclerosis has halted. No new symptoms or lesions on the brain have been reported. The participants did not take any multiple sclerosis medications after they received the high dose immunosuppressive therapy. Studies show that MS medications have a lower chance of success.
This clinical trial referred to as HALT-MS, published its 5 year findings on February 1st in the journal of medicine of the American Academy of Neurology. The study concluded that a one time treatment of the immunosuppressive therapy is more effective than the medications for MS given for long periods of time.
Researchers that were conducting the study, HALF-MS, tested every aspect of HDIT/HCT on willing participants that ranged in ages 26-52 years old. Of these participants, all exhibited inflammation or severe relapses. The trial focuses on suppressing the disease and prevent further progression of the disease.
During the procedure, the physician will collect the volunteers stem cells, then give the patient a high dose of chemo. This lowers the immune system. Then lastly, give back the patient’s stem cells so that it can repair the immune system.
The five year results revealed that the participants were in remission still. Dr. Daniel Rotrosen, said that if these results could be confirmed in bigger trials, this could potentially become a therapeutic option for those with relapsing-remitting multiple sclerosis.
Dr. Shiva Gopal Vasishta is a Neurologist that works in Voorhees, NJ. He graduated in 1979 from the Government Medical College. He has practiced for nearly 40 years. Vasishta did his residency at the Boston City Hospital. His specialty is in Psychiatry. Dr. Shiva Gopal Vasishta practice accepts most insurances. He is board certified and practices at Eastern Neurodiagnostic Associates.